- #British pharmaceutical codex pdf 2016 and reviews pdf#
- #British pharmaceutical codex pdf 2016 and reviews archive#
#British pharmaceutical codex pdf 2016 and reviews archive#
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#British pharmaceutical codex pdf 2016 and reviews pdf#
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Levodopa can easily cross the blood-brain barrier via an amino acid carrier and is then converted (decarboxylated) into dopamine by dopa decarboxylase with the CNS. Thus its prodrug levodopa is used for the treatment of Parkinson’s disease. But dopamine is essential for the treatment of Parkinson’s disease. Enalaprilat is poorly absorbed from the gastrointestinal tract (less than 10%), but absorption of the prodrug enalapril is greatly improved (about 60%).ĭopamine cannot be distributed into the central nervous system (CNS) as it cannot cross the blood-brain barrier. These prodrugs are produced by esterification of the polar carboxylate group to form lipophilic, enzymatically labile esters.Įnalapril is the ethyl ester prodrug of the active diacid, enalaprilat. Pivampicillin, talampicillin and bacampicillin are all prodrugs of ampicillin.